(A) Transport of drugs trough a membrane by means of diffusion

(B) Transport without energy consumption

(C) Engulf of drug by a cell membrane with a new vesicle formation

(D) Transport against concentration gradient (✓)

(A) Low ability to penetrate through the cell membrane lipids (✓)

(B) Penetrate through membranes by means of endocytosis

(C) Easy permeation through the blood-brain barrier

(D) High reabsorption in renal tubules

(A) Lipid-soluble

(B) Non-ionized substances

(C) Hydrophobic substances

(D) Hydrophilic substances 

(a) Active transport (carrier-mediated diffusion)

(B) Filtration (aqueous diffusion)

(C) Endocytosis and exocytosis

(D) Passive diffusion (lipid diffusion) (✓)

(A) Pharmacological effects of drugs

(B) Unwanted effects of drugs 

(C) Chemical structure of a medicinal agent

(D) Distribution of drugs in the organism

(A) The study of biological and therapeutic effects of drugs

(B) The study of absorption, distribution, metabolism and excretion of drugs 

(C) The study of mechanisms of drug action

(D) The study of methods of new drug development002. What does “pharmacokinetics” include?

(A) 2-3 half-lives
(B) 4-5 half-lives
(C) 6-7 half-lives
(D) 8-10 half-lives

(A) ionized drugs are likely to cross into the CSF than unionized drugs
(B) the higher the lipid solubility of a drug, the more likely it will cross into the CSF
(C) inflammation of the meninges improves the likelihood that drugs will cross the BBB as compared to an uninflamed state

(D) None of These

(A) production of a more water-soluble moiety that is more easily excreted
(B) a drug with a different pharmacological mechanism of action
(C) a new compound that may also possess pharmacologic activity
(D) a drug molecule that may undergo enterohepatic recirculation and reintroduction into the bloodstream